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KMID : 0923620210210010002
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Immune Network
2021 Volume.21 No. 1 p.2 ~ p.2
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SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals
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Rha Min-Seok
Kim A-Reum
Shin Eui-Cheol
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Abstract
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In the current review, we describe SARS-CoV-2-specific CD4+ and CD8+ T-cell responses in acute and convalescent COVID-19 patients. We also discuss the relationships between COVID-19 severity and SARS-CoV-2-specific T-cell responses and summarize recent reports regarding SARS-CoV-2-reactive T cells in SARS-CoV-2-unexposed individuals. These T cells may be cross-reactive cells primed by previous infection with human common-cold coronaviruses. Finally, we outline SARS-CoV-2-specific T-cell responses in the context of vaccination. A better understanding of SARS-CoV-2-specific T-cell responses is needed to develop effective vaccines and therapeutics.
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KEYWORD
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SARS-CoV-2, COVID-19, T cell
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